Formic Acid
Formic acid (HCOOH) is naturally-occurring, flammable, corrosive, organic, and the simplest carboxylic acid. Used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
Formic or methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH. At ambient temperatures, it has a strong, penetrating odor, like acetic acid. Used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.
Formic acid occurs naturally in the venom of some ants and bees. Formate, the conjugate base of formic acid, also occurs naturally in bodily fluids following methanol poisoning.
Formic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions. It is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Although formic acid is easily metabolized and eliminated, it can have toxic effects. Methanol metabolism produces formic acid and formaldehyde, which are responsible for the optic nerve damage that results from methanol poisoning. Chronic exposure in humans may cause kidney damage and skin allergies in some people.
In diluted forms, formic acid and formate esters are used as artificial flavorings and perfume additives. In higher concentrations, formic acid is flammable, and skin and eye contact with concentrated liquid or vapors is dangerous.
In agriculture, formic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites. It is useful in leather tanning, textile dyeing and finishing, and in rubber production. Formic acid replaces mineral acids in limescale removers and other cleaning products.
Medchemexpress LLC CBI1 formic | 461.40 | C16H21BrN4O3S2 | 10 MG
CBI1 formic is a covalent small-molecule inhibitor of BAX that selectively derivatizes the protein at cysteine 126 (C126), preventing BAX activation. Supplied for research use, structural and storage information is provided by the manufacturer.
- Covalent BAX inhibitor that derivatizes C126.
- Inhibits BAX activation induced by ligands or point mutations.
- Offered as a solid with sealed, moisture-free storage recommendations.
- Molecular formula C16H21BrN4O3S2; molecular weight 461.40.
- Available in small research pack sizes, including 10 mg.
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC LCC-12 formic | 3029253-76-4 | 99.85% | 460.57 | 25 MG
LCC-12 formic is a dimer of metformin that targets mitochondrial copper(II), leading to a decrease in the NAD(H) pool and modulation of inflammatory responses. It reduces inflammation in mouse models of bacterial and viral infections and serves as a tool for investigating metabolic diseases through its effects on cell plasticity and epigenetic programming.
- Targets mitochondrial copper(II).
- Leads to a decrease in the NAD(H) pool.
- Modulates inflammatory responses.
- Reduces inflammation in mouse models of bacterial and viral infections.
- Serves as a tool for investigating metabolic diseases through its effects on cell plasticity and epigenetic programming.
Medchemexpress LLC Ivaltinostat (formic) | 98.3% | 473.56 | 1 MG
Ivaltinostat formic is an orally active, potent pan-HDAC inhibitor that features a hydroxamic acid moiety designed to bind zinc at the catalytic pocket. It inhibits deacetylation of histone H3 and tubulin, inducing p53 accumulation and promoting p53-dependent transactivation. This compound enhances the expression of MDM2 and p21 proteins, increases sensitivity of Gemcitabine-resistant cells to therapies, induces apoptosis, and demonstrates anti-tumour effects.
- Potent pan-HDAC inhibitor
- Inhibits deacetylation of histone H3 and tubulin
- Promotes p53-dependent transactivation
- Enhances expression of MDM2 and p21 proteins
- Increases sensitivity of drug-resistant cells
- Induces apoptosis
- Exhibits anti-tumour effects
- Attenuates oxidative stress and inflammation
Sigma Aldrich Fine Chemicals Biosciences Formic acid ACS reagent, 88-91, 64-18-6, MFCD00003297
Formic acid ACS reagent, 88-91
Covachem LCMS GRD FORMC ACID ULTPR 25ML
LCMS Grade Formic Acid (UltraPure). 25 mL Bottle. Appearance: Clear liquid. Purity: is ≥ 99%. Storage: Room Temperature. 64-18-6.
LifeSensors Ubiquitin Mass Spectrometry Kit
Mass spectrometry (MS) proteomics, especially when combined with TUBE technologies for protein enrichment, can be used in several innovative and impactful applications. Quantitatively profiling the ubiquitome can lead to the identification of ubiquitination sites on target proteins, and by extension unveiling the mechanisms of undiscovered E3 ligases with their substrates. MS can also inform small molecule drug discovery for these targets (e.g. PROTACs, molecular glues) by quantitatively reporting on how much target protein is degraded in the presence or absence of a drug candidate. This approach can also greatly aid the discovery and development of novel diagnostic biomarkers for challenging disease targets and development of clinically monitoring disease progression. All these applications require a simple, label-free, rapid ubiquitome approach. This kit is designed to address this for rapid yet reproducible proteomics. *The plate is designed for research use only.
Sigma Aldrich Fine Chemicals Biosciences Formic acid | 64-18-6 | MFCD00003297 | 100mL
Formic acid | Purity: ≥88% | MW:46.03 | 64-18-6 | MFCD00003297 | 100mL
Sigma Aldrich Fine Chemicals Biosciences SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES
NC3982132 FORMIC ACID 98-100 FOR HPLC L
Sigma Aldrich Fine Chemicals Biosciences Formic acid >=95%, FCC, FG | 64-18-6 | MFCD00003297 | 1KG
Formic acid >=95%, FCC, FG | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 1KG